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Updated: Sep 10, 2025

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Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
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子どもにおける局所麻酔に対する過敏反応の30年間の経験
Melike Ocak1, Fatma Bal Çetinkaya1, Ayşegül Akarsu1
1Department of Pediatric Allergy, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
まとめ
本物の局所麻酔 (LA) アレルギーは子供ではまれで,反応が疑われる患者の 4. 3% に影響する. 主な危険因子には,疹とアナフィラキシー歴があるため,慎重に診断する必要がある.
科学分野:
- アレルギーと免疫学
- 小児医学
- 薬理学について
背景:
- 小児局所麻酔 (LA) アレルギーに関するデータは限られている.
- 子供のLAアレルギーの診断検査結果は文献ではほとんどありません.
研究 の 目的:
- 30年間の小児患者の真の局所麻酔剤 (LA) アレルギーの有病率を決定する.
- 子供の真のLAアレルギーに関連する危険因子を特定する.
主な方法:
- 直接的なLAアレルギーの疑いのある231人の子供の臨床データと診断試験の結果が評価されました.
- アルチカイン,リドカイン,プリロカイン,メピバカインを含む様々な局所麻酔剤の皮膚刺傷検査 (SPT) と皮膚内検査 (IDT) を実施した.
主要な成果:
- 真のLAアレルギーは,研究された小児患者の4. 3%で確認された.
- 粘膜皮質反応は最も一般的な症状 (90%) でした.
- 真のLAアレルギーの危険因子には,ウルティカリア,アナフィラキシー歴,アルティカインによる検査,およびアトピーの家族歴が含まれています.
結論:
- 本物の局所麻酔 (LA) アレルギーは,小児患者の4. 3%で診断され,以前報告されたよりわずかに高い割合です.
- IgE媒介によるLAアレルギーは,広く使用されているため,予想より少ないが,稀ではない.
- 特定の症状と患者の病歴は,子供におけるLAアレルギーのリスクの増加を示唆している.
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