関連する実験動画

Updated: Sep 10, 2025

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS
09:20

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS

Published on: August 10, 2017

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5HT6対抗性/HDAC6阻害性を持つインテピルジン誘導体

Andreas Gkanas1, Maria Koutiva1, Theodora Katsila2

  • 1Department of Chemistry, University of Patras, Rio Campus, Achaia, 26504, Greece.

Chemistry (Weinheim an der Bergstrasse, Germany)
|August 22, 2025
PubMed
まとめ

研究者らは,5-HT6受容体とHDAC6酵素の両方を標的とした新しい二重作用薬を開発しました. この化合物は アルツハイマー病などの 認知機能の改善に 役立つ可能性を示しています

キーワード:
5HT6抗体アルツハイマー病ブックワルド-ハートウィッグ N-アリレーションHDAC6 阻害剤T3Pアミド合成認知障害認知症ハイドロキサム酸インテピルジンマルチターゲティング指向リガンドキノリン・ウルマン型カップリング硫化物からスルフォンへの酸化

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Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b10:20

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