エイジェクション分数を維持した心不全 (HFpEF) と,エイジェクション分数減少した心不全 (HFrEF) の性別によるリスク変動に関する遡及比較研究
Kristen Yeh1, Mariam Ansar2, Hera Jamal2
1Cooper Medical School of Rowan University, Camden, New Jersey, USA.
Journal of primary care & community health
|August 22, 2025
まとめ
心不全 (HF) の危険因子は男性と女性によって異なります. HFpEFの女性は,高齢者,喘息,関節炎,うつ病,甲状腺機能低下,および不安症の有病率が高かった. 黒人人種は女性におけるHFrEFと関連していた.
科学分野:
- 心臓病科
- 公衆衛生
- 流行病学について
背景:
- 心不全 (HF) の罹患率は米国で増加しており,2030年までに850万人に達すると予測されています.
- 男性と女性の発症とリスク要因は異なります.
- 性別別の違いを理解することは 標的型予防と治療戦略に不可欠です
研究 の 目的:
- 女性と男性の心不全に関連するリスク要因を調査し,比較する.
- 女性における異なるタイプのHF (HFpEFとHFrEF) に関する特定の併発症と人口統計的要因を特定する.
主な方法:
- 診断されたHFの成人の患者の医療記録の遡及的レビュー.
- 発射率を保持した心不全 (HFpEF) と発射率を減少した心不全 (HFrEF) と診断された女性と男性の変数の比較
主要な成果:
- HFpEFを持つ女性は,男性に比べて高齢化,喘息,骨関節炎,うつ病,甲状腺機能低下,および不安症の罹患率が高かった.
- 女性におけるHFpEFの確率の増加に関連する要因には,高齢者,BMIの上昇,関節疾患,精神疾患,喘息,甲状腺機能低下などが含まれる.
- HFrEFの場合,女性は喘息,うつ病,甲状腺機能低下症,および不安症のより高い罹患率を示した. 黒人人種は女性におけるHFrEFのより高い確率と関連していた.
結論:
- 女性では,HFpEFは高齢化,BMI上昇,骨格関節炎と関連しています.
- 黒人人種は女性におけるHFrEFの重要な危険因子です.
- 喘息,うつ病,不安,甲状腺機能低下は,女性におけるHFpEFとHFrEFの両方に関連しており,統合ケアが必要であることを強調しています.
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