Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

213
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
213
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

119
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
119
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

55
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
55
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

78
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
78
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

32
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
32
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

33
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
33

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

The prognostic value of lncRNA AGAP2-AS1 in cancer patients: A meta-analysis.

Medicine·2021
Same author

Nomogram Models to Predict Postoperative Hyperlactatemia in Patients Undergoing Elective Cardiac Surgery.

Frontiers in medicine·2021
Same author

Synthesis and evaluation of highly releasable and structurally stable antibody-SN-38-conjugates.

Drug delivery·2021
Same author

[Insight into the role of IGF2BP1 in drug resistant mechanism of oral squamous cell carcinoma].

Shanghai kou qiang yi xue = Shanghai journal of stomatology·2021
Same author

Effects of Cigarette Smoking on Resting-State Functional Connectivity of the Nucleus Basalis of Meynert in Mild Cognitive Impairment.

Frontiers in aging neuroscience·2021
Same author

Intra-articular Injection of Lornoxicam and MicroRNA-140 Co-loaded Cationic Liposomes Enhanced the Therapeutic Treatment of Experimental Osteoarthritis.

AAPS PharmSciTech·2021

関連する実験動画

Updated: Sep 10, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.4K

血と高感度C反応性タンパク質の血性指数と心血管疾患の関連:中年および高齢の中国人コホートからの証拠

Ping-An Lian1, Fei Xie1, Wei Zhang1

  • 1Department of Cardiology, Seventh People's Hospital of Zhengzhou, Zhengzhou, Henan, China.

Frontiers in endocrinology
|August 22, 2025
PubMed
まとめ
この要約は機械生成です。

血動脈指数 (AIP) と高感度C反応性タンパク質 (hs- CRP) の上昇は,心臓血管疾患 (CVD),特に脳卒中のリスクを大幅に増加させる. 高齢者のリスク予測を改善する可能性がある.

キーワード:
C反応性タンパク質チャールズ血性指数 血性指数心血管疾患炎症縦断的なコホート研究

さらに関連する動画

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
07:35

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

2.1K
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.4K

関連する実験動画

Last Updated: Sep 10, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.4K
Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
07:35

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

2.1K
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.4K

科学分野:

  • 心血管疾患の研究
  • バイオマーカーの分析
  • エピデミオロジー

背景:

  • 血性指数 (AIP) と高感度C反応性タンパク質 (hs- CRP) は心血管疾患 (CVD) と関連しています.
  • AIPとhs-CRPがCVDリスクに及ぼす影響と相互作用のメカニズムについては,さらなる調査が必要である.

研究 の 目的:

  • AIPとhs-CRPのCVDリスクとの独立した関連性を評価する.
  • CVDの発達におけるAIPとhs-CRPのメディエーション効果と添加的相互作用を探求する.
  • 結合されたAIPとhs-CRPのCVDの予測性能を評価する.

主な方法:

  • 中国保健・退職長期研究 (CHARLS) の8,763人の成人 (≥45歳) のデータを利用し,最大9年間の追跡調査を行った.
  • 多変数Coxモデル,メディエーション分析,相互作用による相対的過剰リスク (RERI) を用いて,関連と相互作用を評価した.
  • 受信機操作特性 (ROC) 曲線解析を用いて予測性能を評価した.

主要な成果:

  • AIPとhs- CRPの値が高くなるのは,独立して心血管疾患のリスクの増加と関連していた.
  • AIPとhs-CRPの両方のレベルが上昇した個人は,特に脳卒中 (HR: 2,207) のために,最も高いCVDリスクを示しました.
  • hs- CRPはAIP- CVD関連性の6. 6%,AIPはhs- CRP- CVD関連性の20. 3%を媒介し,潜在的陽性添加相互作用が観察された (RERI=0. 141).
  • 統合モデルでは,個々のマーカーと比較して優れたCVD予測 (AUC=0. 590) が示され,脳卒中予測の最適性能 (AUC=0. 615) が示された.

結論:

  • AIPとhs-CRPの合同上昇は,心血管疾患と脳卒中のリスクを大幅に増加させます.
  • 相互の媒介と潜在的添加的相互作用は,CVDの病原性における脂質代謝と炎症の相互関係を示唆する.
  • AIPとhs-CRPの両方をリスク評価モデルに統合することで,中年および高齢者の早期CVD検出と予防戦略を向上させることができます.