人体測定指標と糖尿病:ラフサンジャンのコホート研究に基づく
Fatemeh Ayoobi1, Fatemeh Ranjbarhasanabadi2, Parvin Khalili3,4
1Occupational Safety and Health Research Center, NICICO, World Safety Organization and Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
International journal of preventive medicine
|August 22, 2025
まとめ
腰から腰までの比率 (WHR) と腰から身長までの比率 (WHtR) は,2型糖尿病 (T2DM) のリスクの強い予測指標である. 腰周 (WC) は最も弱い関連性を示し,T2DMの人体測定指標の予測能力が異なることを示した.
科学分野:
- 内分泌学
- 公衆衛生
- エピデミオロジー
背景:
- 2型糖尿病 (T2DM) リスクに対する人体測定指標の予測能力については,異なった結果が出ています.
- この研究は,ラフサンジャンのコホート研究における人体測定指標とT2DMを調査することで,これらの矛盾を解決します.
研究 の 目的:
- 様々な人体測定指標とT2DMの発症リスクとの関係を調査する.
- 研究対象集団におけるT2DMの予測に最も効果的で最も効果的でない人体測定指標を特定する.
主な方法:
- イランのラフサンジャンコホート研究 (RCS) の35~70歳の9895人の成人を対象とした横断的な研究.
- T2DMは,空腹の血糖値> 126 mg/ dLまたは血糖を下げる薬の使用によって定義されました.
- 腰から股関節までの比率 (WHR),腰から身長までの比率 (WHtR),および腰周 (WC) を含む人体測定指標は,T2DM/前糖尿病状態に対して分析された.
主要な成果:
- 参加者の約23%がT2DMで35%が前糖尿病でした.
- 混同因子を調整すると,WHR (OR=3.25) とWHtR (OR=2. 90) の最高四分位数は,T2DMの確率の増加と有意に関連していました.
- 体重過多,肥満,不正常な WC もT2DMの確率の上昇と関連していました.
結論:
- このコホートにおけるT2DMリスク予測における最も強力な人体測定指標として WHRが登場しました.
- WCは他の指標と比較してT2DMリスクと最も弱い関連性を示した.
- これらの発見は,T2DMの人類測定値の予測値の違いを強調しています.
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