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リンパ腫に由来する細胞外小胞は,CAR T細胞機能を阻害する

Khadiza Siddika1, Katie R Flaherty1, Reuben Benjamin2,3

  • 1Department of Infectious Diseases, King's College London, London, England, United Kingdom.

microPublication biology
|August 22, 2025
PubMed
まとめ

リンパ腫に由来する細胞外小胞 (EV) は,B細胞マーカーを移転し,抗腫瘍活性を抑制することで,CD19を標的とするCAR T細胞療法を阻害する可能性があります. この発見は,一部のB細胞リンパ腫患者の治療耐性を説明する可能性がある.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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