関連する実験動画

Updated: Sep 10, 2025

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
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Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons

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IRE1αは,膀がんにおけるERストレス調節によるM1腫瘍ウイルス感受性を調節する

Cheng Hu1,2, Song Wei1,2, Wenbo Zhu3,2

  • 1Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, Guangdong, China.

Cancer drug resistance (Alhambra, Calif.)
|August 22, 2025
PubMed
まとめ

IRE1αを阻害すると,筋肉侵襲性膀がんの腫瘍性ウイルス療法が強化され,エンドプラズマ網膜のストレスとM1ウイルス誘発のアポトーシスが促進されます. この戦略は腫瘍抑制を改善し,より良い治療結果をもたらす可能性があります.

キーワード:
ERのストレスIRE1αM1型腫瘍ウイルスUPR について膀 がん

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The ER is the hub of protein synthesis in a cell. It has robust systems to quality control protein folding and also for degradation of terminally misfolded proteins. Under normal conditions, a small proportion of misfolded proteins that cannot be salvaged need to be transported to the cytoplasm by the ER-associated degradation or ERAD pathways. However, if the ERAD cannot handle the misfolded proteins, the cell activates the unfolded protein response or UPR to adjust the protein folding...
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