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Updated: Sep 10, 2025

Functional Reconstitution and Channel Activity Measurements of Purified Wildtype and Mutant CFTR Protein
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Functional Reconstitution and Channel Activity Measurements of Purified Wildtype and Mutant CFTR Protein

Published on: March 9, 2015

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CFTR の 折り畳み,成熟,チャンネル 活動 の 欠陥 を 修正 する ため の 小分子 の 使用

Meredith F N Rosser1, Diane E Grove1, Douglas M Cyr1

  • 1Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Current chemical biology
|August 22, 2025
PubMed
まとめ

胞性線維症 (CF) は,タンパク質の折りたたみ,移動,機能に影響するCFTR遺伝子変異によって引き起こされます. 研究は CFの治療のためにこれらの欠陥を修正し,CFTRチャネル活動を回復するために小分子に焦点を当てています.

キーワード:
胞性線維症ER 品質管理付随する人コレクターパンチエーター

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