薬物乱用患者のフェニラミン乱用の現状:範囲,パターン,および臨床的影響に関する記述的レビュー
Raja Babu Ramawat1, Omar Afroz1, Rizwana Quraishi2
1National Drug Dependence Treatment Centre & Department of Psychiatry, AIIMS, New Delhi, India.
The International journal of risk & safety in medicine
|August 22, 2025
まとめ
フェニラミンは 処方箋なしで売れる抗ヒスタミンで 薬物乱用や依存症の可能性があり オピオイドと併用することが多い 臨床医は,特に薬物乱用患者の症状に注意する必要があります.
科学分野:
- 薬理学について
- 公衆衛生
- 臨床医学
背景:
- 処方箋外 (OTC) の薬は,世界中で誤用に関する懸念が高まっています.
- フェニラミンは,アレルギーに対する第一世代の抗ヒスタミンであり,最初の安全感に反して,誤用の可能性と依存性が認められています.
- フェニラミンは,注射薬物使用でしばしばオピオイドと混合され,違法に使用されていることを示唆しているが,まだ十分に研究されていない.
研究 の 目的:
- フェニラミンの誤用に関する既存の文献をレビューする.
- フェニラミンの誤用とその臨床的影響に関する症例報告を要約します.
主な方法:
- PubMed,Google Scholar,MedSearchを使用して,包括的な文献検索が行われました.
- フェニラミン乱用,乱用,依存症,および関連する薬物乱用に焦点を当てた英語,ピアレビュー,およびPubMedインデックスされた記事は含まれていた.
- キーワードには"フェニラミンの使用"",乱用"",乱用"",依存"",有害な使用"",薬物使用障害"",オピオイド使用障害"および"注射薬物使用者"が含まれています.
主要な成果:
- フェニラミンはロラゼパムと同様の乱用の可能性があり,特に南アジアでは,しばしばオピオイドおよび/またはディアゼパムと注射されます.
- 南アジアの研究では,フェニラミンの併発性使用は注射薬物使用者の15%~80%で,患者の報告が不足していることが示されています.
- 8件以上の症例報告はフェニラミンの乱用/依存症を詳細に説明し,発作,精神病,生命を脅かす毒性に関連しており,容易なアクセスが潜在的な要因である.
結論:
- フェニラミンの乱用は公衆衛生上の問題として 増大しています
- 医療従事者はフェニラミン乱用の兆候に注意を向けるべきであり,特に薬物乱用と精神疾患が併発する個体には注意を向けるべきである.
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