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Updated: Sep 10, 2025

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Gα13 中部前頭皮質の過剰発現は,Adcyap1/cAMP/PKA/NMDAR経路を通じて社会的行動を妨害する

Rui Fan1,2, Jianlin Pu1,2, Jin Zhang1

  • 1Department of Psychiatry, Fundamental and Clinical Research on Mental Disorders Key Laboratory of Luzhou, Institute of Cardiovascular Research, The Affiliated Hospital, Southwest Medical University, Taiping Street 25, Jiangyang district, Luzhou, Sichuan, 646000, China.

Schizophrenia bulletin
|August 22, 2025
PubMed
まとめ

マウスにおけるGα13の過剰発現は,神経機能を阻害することで,社会的行動を損なう.これは統合失調症 (SCZ) に関連する発見である. Gα13をターゲットにすることで,SCZの社会的欠陥に対する新しい治療戦略を提供することができる.

キーワード:
Adcyap1; Gα13; 中間前頭皮質NMDA受容体について統合失調症社会的な赤字

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