多発性硬化症の若い成人の腸機能障害: 遡及的研究
Edoardo Sessa1, Lilla Bonanno1, Carla Susinna1
1IRCCS Centro Neurolesi Bonino Pulejo, 98123 Messina, Italy.
Medical sciences (Basel, Switzerland)
|August 22, 2025
まとめ
腸の機能障害は多発性硬化症 (MS) の若い成人の生活の質に大きく影響し,身体的,感情的,社会的福祉に影響します. これらの症状の治療は 患者の全般的な改善に不可欠です
科学分野:
- 神経学
- 胃腸内科
- 生活の質に関する研究
背景:
- 多発性硬化症 (MS) は若年層に影響を与える慢性神経変性疾患です
- 便秘と排泄不全を含む腸機能障害は,MSで顕著だが,しばしば見過ごされる症状である.
- BDは特に若いMS患者の身体的,感情的,社会的幸福に悪影響を及ぼします.
研究 の 目的:
- 再発性寛解性MS (RRMS) と軽度の障害を持つ若者の生活の質 (QoL) に対する腸機能障害の影響を調査する.
- QoLドメインの減少と最も強く相関する特定の腸の症状を特定する.
主な方法:
- 110人の若年成人RRMS (EDSS ≤3. 5) を対象とした遡及的横断研究.
- 腸の症状の評価は,ウェクスナー失禁と便秘のスケールを使用します.
- MSQoL-54アンケートと統計的相関分析を用いたQoLの測定
主要な成果:
- 腸の症状の重度と複数のQOL領域 (身体的,感情的,社会的機能) の間に有意な相関が発見されました.
- 腹痛と排泄不便は,精神的および身体的健康スコアが低いと強く関連していました.
- 性別別別別の差異が観察され,女性は社会的,感情的な幸福に明確な影響を及ぼします.
結論:
- 腸機能不全はMSの若い成人のQOLに重大な負担を課します.
- 身体的,心理的,社会的側面に対応する 統合的,多学科的なケアが 緊急に必要です
- この患者集団の総合的な健康改善には 総合的な臨床アプローチが不可欠です
関連する概念動画
Chronic Bowel Disorders: Introduction
540
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
540
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
245
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
245
Irritable Bowel Syndrome I: Introduction
375
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
375
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
419
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
419
Assessment of the Rectum and Anus
400
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
400
Irritable Bowel Syndrome III: Medical and Nursing Management
301
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
301


