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Updated: Sep 10, 2025

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ヴィルダグリプチン関連ブルス型ペンフィゴイドの症例シリーズ - 希少な副作用

Mohit Kumar Shahi1, J V Ashwin1, Astha Singh2

  • 1Department of GMH, King George Medical University, Lucknow, Uttar Pradesh, India.

Indian journal of pharmacology
|August 22, 2025
PubMed
まとめ

ビルダグリプチンは,一般的な経口低血糖剤で,泡状の皮膚疾患であるブルース・ペムフィゴイドを誘発する可能性があります. この症例シリーズは,2型糖尿病のヴィルダグリプチン投与を開始した後にこの自己免疫疾患を発症した3人の患者を強調しています.

キーワード:
ブルース・ペムフィゴイド糖尿病ディペプチジルペプチダゼ-4ビルダグリプチン

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Dipeptidyl Peptidase 4 Inhibitors

Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
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Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
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