関連する実験動画

Updated: Sep 10, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

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トール型受容体4の活性化により,マウンの肝細胞におけるファルネソイドX受容体の転写抑制により,ヴォリコナゾール誘発の肝毒性が強化される

Xiaokang Wang1, Chenyu Zhao2, Yuxian Chen3

  • 1Department of Pharmacy, Shenzhen Longhua District Central Hospital, 187 Guanlan West Road, Longhua District, Shenzhen 518110, China.

The Journal of pharmacy and pharmacology
|August 22, 2025
PubMed
まとめ

トール型受容体4 (TLR4) の活性化は,核受容体FXRを抑制することによって,ヴォリコナゾール (VRC) 誘発の肝損傷に寄与する. TLR4を阻害すると,VRCの肝毒性から保護され,新しい治療目標を示唆する.

キーワード:
胆酸ファルネソイドX受容体肝毒性トール型受容体 4ボリコナゾール

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