血清尿酸とがんの相関: 43のコホート研究の体系的な評価と投与量反応メタ解析
Xinfu Liu1, Huixiang Chen2, Serong Wang3
1Department of Medical Oncology, Shaoyang Central Hospital, Hunan Province, China.
International journal of surgery (London, England)
|August 22, 2025
まとめ
血清尿酸 (SUA) は全体的ながん発生率や死亡率と関連していません. しかし,高濃度のSUAは,特に女性および特定の癌の生存率の低下と関連しています.
科学分野:
- 腫瘍学
- 生物化学
- 流行病学について
背景:
- 血清尿酸 (SUA) と癌の関係については議論が続いている.
- 癌の予後におけるSUAの役割に対する関心が高まっている.
研究 の 目的:
- SUAと癌の発生率,死亡率,および予後を調査するメタ分析を行う.
主な方法:
- 2025年2月までの主要なデータベース (PubMed,Embase,Web of Science,Cochrane Library) の体系的な文献検索
- 95%のCIで関連するリスク評価 (OR,HR,RR) を報告したコホート研究を含む.
- SUAと癌のアウトカムに関するデータを合成するメタ分析.
主要な成果:
- 高いSUAは全体的ながん発生率と有意に関連していない (RR:1. 08).
- 増加したSUAは前立腺がんと正の関連を示し,肺がんの発生率と逆の関連を示し,女性ではより強い相関を示した.
- 高いSUAと全がん死亡率 (RR: 0. 92) の間には有意な関連性が見つかりませんでした.
- 高濃度のSUAは,特に乳がんおよび非小細胞肺がんにおいて,全生存率 (OS) の低下と有意に関連していた (RR: 1.81).
結論:
- 血清尿酸の上昇は,全体的ながん発生率や死亡率と有意に関連していません.
- 血清尿酸は,がんの予後と全生存率の低下と有意に関連しています.
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