食事中の脂肪は炎症性腸疾患の発症リスクの増加と関連している: 系統的レビューと用量反応メタ解析
Song Zhang1, Xiangyu Sui1, Jiahui Wei1
1Department of Gastroenterology, Changhai Clinical Research Unit, Changhai Hospital; National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, China.
International journal of surgery (London, England)
|August 22, 2025
まとめ
脂肪の多い摂取は,炎症性腸疾患 (IBD) のリスクのわずかな増加と関連しています. しかし,長鎖のn-3多不飽和脂肪酸 (LCN-n-3) と高いn3/n6比はIBDの発症に対する保護を提供することができる.
科学分野:
- 胃腸内科
- 栄養学
- 流行病学について
背景:
- 食中の脂肪と炎症性腸疾患 (IBD) の発症の関係については議論されている.
- IBDのリスクにおける特定の脂肪酸の役割は,さらに明確にする必要があります.
研究 の 目的:
- 食中の脂肪摂取とIBD発症のリスクとの関連を調査し,定量化する.
- IBDリスクに対する特定の脂肪酸の影響を調査する.
主な方法:
- 2025年1月までの関連研究について,PubMed,Embase,Web of Scienceで体系的な文献検索が行われました.
- メタアナリシス,サブグループ分析,メタレグレッション,および用量反応評価は,相対リスク (RRs) と95%信頼区間 (CI) を組み合わせるために行われました.
主要な成果:
- 脂肪の総摂取量の増加は,IBD発症リスクの増加とわずかに関連している (RR = 1.24)
- 多過飽和脂肪酸 (PUFA) とコレステロールは,より高いIBDリスクと関連しており,長鎖のn-3 PUFA (LCN- n-3) と高いn3/ n6- PUFA比率は,保護効果を示唆している.
- アジアの男性と若い個体を含む特定の集団は,脂肪に関連したIBDに対する感受性が高かった.
結論:
- 脂肪の摂取量が増加すると,特にPUFAとコレステロールに関して,IBD発症リスクが適度に増加する可能性があります.
- LCN- n-3の摂取量と好ましいn3/ n6- PUFA比はIBDの発症リスクを低下させる可能性がある.
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