関連する実験動画

Updated: Sep 10, 2025

Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis
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Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

Published on: April 1, 2022

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PIEZO1媒介メカニカルトランスデュークション in Craniofacial Biology

Yutong Wang1, Ge Liu1, Zhendong Tao1

  • 1State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|August 22, 2025
PubMed
まとめ

PIEZO1は機械感受性イオンチャネルで,頭蓋骨の発達と骨の恒常性を調節する. PIEZO1をターゲットにすることで,骨粗鬆症や歯周病などの疾患を治療する可能性があるが,臨床応用にはさらなる研究が必要である.

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Tension Response at Adherens Junctions

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Cell-matrix's Response to Mechanical Forces

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Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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