関連する実験動画

Updated: Sep 10, 2025

In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells
08:21

In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells

Published on: March 16, 2017

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WNT媒介のTCF/LEF転写因子の遺伝子発現は,初期のヒトの多能性および細胞系において,歯類のパラダイムとは異なる

Connor Ross1, Paula A Balestrini2, Lawrence E Bates3

  • 1Institute of Medical Sciences, Foresterhill Health Campus, University of Aberdeen, AB25 2ZD, UK.

Journal of cell science
|August 22, 2025
PubMed
まとめ

人間の胚性幹細胞の研究は,マウスと比較して異なるWNT/β-カテニンのシグナル伝達を必要としていることを示しています. TCF/LEF遺伝子の発現は人間の発達段階によって異なるため,シグナル伝達要件に影響します.

キーワード:
人間開発ナイヴ 多能性TCF/LEFの転写因子WNT/β-カタニンシグナリング初期の胚細胞系統胚外細胞系

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