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Updated: Sep 10, 2025

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妊娠中のドキシサイクリンの安全性:
Itamar Ben Shitrit1,2, Daphna Idan1,2, Ariel Avraham Hassidim3,4
1Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 8410501, Israel.
Infection
|August 22, 2025
まとめ
妊娠中のドキシサイクリンの使用は,重大な先天性欠陥と関連していません. ドキシサイクリンが医学的に必要である場合,胎児全体の安全性は好ましいようです.
科学分野:
- 産婦人科
- 薬理学について
- 胎児医学
背景:
- ドキシサイクリンは妊娠中に一般的に処方されていますが,胎児の安全性データは一貫していません.
- 現存する研究では,生きた胎児を除外し,包括的な安全性評価を制限しています.
研究 の 目的:
- 第1期または第3期ドキシサイクリンの暴露と主要な先天性異常との関連を評価する.
- 死産や妊娠中絶を含むドキシサイクリンの暴露と不良結果の関連性を評価する.
主な方法:
- 1998年から2017年の間に265,686人の妊娠を対象とした集団ベースのコホート研究.
- ドキシサイクリンの暴露は,薬局記録を通じて第1 (≤13週) と第3 (≥27週) の三半期に確認された.
- ネガティブ・バイノミアルモデルでは,変形と生理周期のアウトカムに関する相対的なリスクが推定され,感受性分析には,用量-反応と傾向-スコアのマッチングが含まれていた.
主要な成果:
- 最初の3ヶ月間のドキシサイクリンの暴露 (n=2, 696) は,重大な先天性異常と有意な関連性を示さなかった (調整RR=1. 07;95%CI 0. 93-1. 23).
- 臓器特異的発育不全や,ほとんどの妊娠後期における発症リスクの上昇は認められなかった.
- 第3四半期 (n=112) の被曝は,出生時の体重が非常に低いリスクと関連していました.
結論:
- 妊娠中のドキシサイクリンの使用は,主要な先天性異常のリスクの増加と関連していません.
- 大半の妊娠後半の副作用はドキシサイクリンの暴露の影響を受けなかった.
- これらの発見は,ドキシサイクリンが妊娠中に臨床的に示された場合,比較的安全であると考えられることを示唆しています.
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