関連する実験動画

Updated: Sep 10, 2025

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure
08:25

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Published on: June 5, 2020

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ヒトのHepaRG細胞が遺伝子毒性発がん物質に長期にわたって被曝した後に発生した変異の蓄積

Xiaoqing Guo1, Ji-Eun Seo1, Jaime Miranda-Colon1

  • 1Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA.

Journal of environmental science and health. Part C, Toxicology and carcinogenesis
|August 22, 2025
PubMed
まとめ

ヘパRG細胞におけるN- ニトロジメチラミン (NDMA) の長期的曝露は,特に3D培養において,変異の頻度を増加させる. 試験期間が長ければ,化学物質のリスク評価のための in vitro 遺伝子毒性評価が改善されます.

キーワード:
3次元球形肝臓RG細胞エラー修正されたシーケンシング遺伝子毒性変異

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