関連する実験動画

Updated: Sep 10, 2025

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

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大腸がんにおけるユビキチン-プロテアソーム系と薬物治療を標的とする

Ruixin Su1, Yingying Shao2,3, Qian Wang1

  • 1Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.

Journal of molecular cell biology
|August 22, 2025
PubMed
まとめ

Ubiquitin-proteasome system (UPS) をターゲットにすることで,大腸がん (CRC) の治療に新たな希望が生まれます. PROTACsや分子接着剤のような 新しい治療法は 癌の原因となるタンパク質を分解し 蔓延している悪性腫瘍の 治療結果を改善します

キーワード:
大腸がん (CRC)薬物療法分子接着剤タンパク質分解を標的とするキメラ (PROTAC)ユビキチンプロテアソームシステム (UPS)

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Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

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