サルコペニアとない腹腔内透析患者における唾液微生物群:パイロット研究
Wararak Choovanichvong1, Sirirak Supa-Amornkul2, Dulyapong Rungraungrayabkul1
1Department of Oral Medicine and Periodontology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
PloS one
|August 22, 2025
まとめ
末期腎臓病 (ESKD) は唾液の微生物群を大きく変化させ,細菌の数を増やす. サルコペニアの影響は最小でしたが,レプトトリキアはESKDの重要な唾液バイオマーカーとして浮上しました.
科学分野:
- 微生物学
- 腎臓科
- 口腔 衛生
背景:
- 末期性腎臓病 (ESKD) は,全身的な健康上の合併症と関連しています.
- サルコペニア,筋肉の減少は ESKD と同時に頻繁に起こります.
- 慢性疾患では口腔の微生物群の変化がますます認識されています.
研究 の 目的:
- 末期腎疾患 (ESKD) とサルコーペニア (SESKD) の患者,サルコーペニアのないESKD (NSESKD) と健康な対照群の唾液微生物群の組成を比較する.
- ESKDとサルコペニアに関連した潜在的微生物のバイオマーカーを特定する.
主な方法:
- 33人の参加者から唾液サンプルを採取した (10人のSESKD,12人のNSESKD,11人の対照群).
- バクテリアの16S rRNA遺伝子配列 (V3- V4領域) を用いて唾液微生物群の構成を分析した.
- 人口統計データ,口腔の健康,筋肉の強さを評価した.
主要な成果:
- ESKD群 (SESKDとNSESKD) の細菌の総数は対照群と比較して有意に高かった.
- 唾液の微生物群の構成は,ESKDの状態,教育レベル,筋肉の強さによって有意に変化した.
- 特定の属の多様性は変化した: Actinobacillus,TM7x,Capnocytophaga,Neisseria,Leptotrichiaが増加し,ESKD患者ではActinomycesとAtopobiumが減少した.
- レプトトリキアはESKDの潜在的唾液バイオマーカーとして特定されました.
結論:
- 末期腎臓病は唾液の微生物の組成に 大きく影響します
- サルコペニアは,ESKD患者の唾液微生物群に最小限の直接的な影響を及ぼしているようです.
- レプトトリキアはESKDを検出する有望な唾液バイオマーカーです.
関連する概念動画
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
105
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
105
01:50What is Monogastric Digestion?
72.5K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
72.5K
01:25Peritoneal Dialysis III: Nursing Management
140
Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
140
01:23Salivary Glands and Saliva
953
The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
953