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Updated: Sep 10, 2025

In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression
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In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression

Published on: March 29, 2019

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生物学的ネットワークの逆制御により,フェノタイプの景観が回復する

Insoo Jung1, Corbin Hopper1, Seong-Hoon Jang1

  • 1Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.

Science advances
|August 22, 2025
PubMed
まとめ

この研究は,DNA損傷によって変化した生物学的ネットワークを修復するための代数学的逆制御 (ARC) フレームワークを導入します. ARCは,生物学的システムの主要な制御目標を特定することによって,正常な刺激-反応関係を回復します.

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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
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