人間の唾液のタンパク質の遺伝子は,霊長類の進化の過程で形成されました

Petar Pajic^1,2, Luane Landau¹, Omer Gokcumen¹

¹Department of Biological Sciences, University at Buffalo, The State University of New York, NY 14260, USA.

Genome biology and evolution

|August 22, 2025

まとめ

唾液中の分泌カルシウム結合フォスフォタンパク質 (SCPP) 遺伝子は,遺伝子の複製と喪失によって哺乳類において有意に多様化した. SCPP遺伝子の進化的変化は霊長類の口腔健康に影響します

科学分野:

進化生物学
ゲノミクス
哺乳類の進化

背景:

分泌性カルシウム結合フォスフォプロテイン (SCPP) 遺伝子ロクスは,主要な脊椎動物の進化の出来事と一致する多様化を経験した.
SCPP遺伝子は特に人間の唾液で発現し,口腔生物学における役割を示唆しています.

研究の目的:

ゲノムとトランスクリプトミックのデータを用いて,唾液に関連するSCPP遺伝子の進化史と多様化を調査する.
唾液腺発現に関わるSCPP遺伝子の進化を駆動するメカニズムを理解する.

主な方法:

哺乳類のSCPP遺伝子の遺伝子解析
比較ゲノミクスは遺伝子の複製,損失,規制のシフトを特定します
霊長類のSCPP遺伝子におけるポジティブセレクションシグネチャーの検出

主要な成果:

哺乳類のSCPP遺伝子の広範な多様化,特に唾液腺の遺伝子の複製と損失によって引き起こされる.
ネズミとヒトの唾液腺発現を加速する調節的シフトと遺伝子ターンオーバーの証拠
最近の重複と,霊長類の唾液に関連するSCPP遺伝子で確認された陽性選択は,他の場所の保存されたSCPP遺伝子と対照的です.

結論:

唾液に関連したSCPP遺伝子は高度に適応し,急速な進化的な革新を経験しています.
食事と病原性の圧力により,唾液SCPP遺伝子の機能が形成され,霊長類の口腔健康,代謝,免疫に影響を与えました.

キーワード:

遺伝子の複製遺伝子ターンオーバーミルク・カゼイン唾液のタンパク質歯のエナメル

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