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Updated: Sep 10, 2025

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
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Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line

Published on: May 10, 2017

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SOX11は,BTK抵抗性マントル細胞リンパ腫における治療標的化のためのPAX5/CD19軸を通じたBCRシグナリングを調節する

Rudra Prasad Dutta1, Heng-Huan Lee2, Violetta V Leshchenko1

  • 1Icahn School of Medicine at Mount Sinai, New York, New York, United States.

Blood advances
|August 22, 2025
PubMed
まとめ

SOX11は,BCRシグナル伝達を活性化することによって,マントル細胞リンパ腫におけるブルトンチロシンキナーゼ阻害剤耐性を駆動する. SOX11をSOX11iで標的にすることは,臨床前モデルを含む耐性MCLの治療に有望である.

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