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テンポラル・ロブ・エピレプシー患者における成人の生涯におけるグレーマターの形態と白質の微細構造の変化

Judy Chen ¹, Alexander Ngo ¹, Raul Rodriguez-Cruces ¹

¹Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
²Neuroscience Research Center, University Magna Græcia, Catanzaro, Italy.
³Institute of Neurology, University Magna Græcia, Catanzaro, Italy.
⁴Institute of Neurobiology, Universidad Nacional Autónoma de México, Querétaro.
⁵Institute of Systems, Molecular and Integrative Biology, University of Liverpool, United Kingdom.
⁶Walton Centre NHS Foundation Trust, Liverpool, United Kingdom.
⁷Department of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
⁸Department of Neurology, Emory University, Atlanta, GA.
⁹Department of Neurology, University of Medicine Göttingen, Germany.
¹⁰Institute of Diagnostic Radiology and Neuroradiology, Functional Imaging Unit, University Medicine Greifswald, Germany.
¹¹Department of Neurology, University Medicine Greifswald, Epilepsy Center, Germany.
¹²Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Germany.
¹³Support Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Switzerland.
¹⁴Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Germany.
¹⁵Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Germany.
¹⁶Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Australia.
¹⁷Departments of Medicine and Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Australia.
¹⁸Scientific Institute IRCCS E. Medea, Epilepsy Unit, Conegliano, Italy.
¹⁹Department of Biomedical, Metabolic and Neural Science, University of Modena and Reggio Emilia, Italy.
²⁰Neurology Unit, OCB Hospital, Azienda Ospedaliera-Universitaria, Modena, Italy.
²¹Primary Care Department, Azienda Sanitaria Locale di Modena, Italy.
²²Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin.
²³Department of Neurology, Alpert Medical School of Brown University, Providence, RI.
²⁴Department of Neurology, St James' Hospital, Dublin, Ireland.
²⁵FutureNeuro SFI Research Centre, Dublin, Ireland.
²⁶Epilepsy Center, Neuro Center, Kuopio University Hospital, Member of the European Reference Network for Rare and Complex Epilepsies EpiCARE, Finland.
²⁷Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio.
²⁸Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia.
²⁹Neuroradiology Research Program, Meyer Children Hospital of Florence, University of Florence, Italy.
³⁰Transitional and Clinical Research Institute, Newcastle University, United Kingdom.
³¹Contol and Intelligent Processing Center of Excellence (CIPCE), School of Electrical and Computer Engineering, University of Tehran, Iran.
³²Departments of Research Administration and Radiology, Henry Ford Health System, Detroit, MI.
³³Department of Neurology, Henry Ford Health System, Detroit, MI.
³⁴Cognitive Science Department, Xiamen University, China.
³⁵Child Neurology Unit and Laboratories, Neuroscience Department, Meyer Children's Hospital IRCCS, Florence, Italy.
³⁶Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Italy.
³⁷IRCCS Stella Maris Foundation, Pisa, Italy.
³⁸Cardiff University Brain Research Imaging Centre (CUBRIC), College of Biomedical and Life Sciences, Cardiff University, United Kingdom.
³⁹The Welsh Epilepsy Unit, Department of Neurology, University Hospital of Wales, Cardiff, United Kingdom.
⁴⁰Department of Neuroradiology, University Hospital Bonn, Germany.
⁴¹Department of Epileptology, University Hospital Bonn, Germany.
⁴²Institute of Experimental Epileptology and Cognition Research, University Hospital Bonn, Germany.
⁴³Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Quebec, Canada.
⁴⁴Department of Neurology, Hôpital Erasme, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Belgium.
⁴⁵Department of Radiology, Hôpital Erasme, Université Libre de Bruxelles, Belgium.
⁴⁶School of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.
⁴⁷Department of Neurology, NYU Grossman School of Medicine, New York, USA.
⁴⁸IRCCS Istituto Giannina Gaslini, Genova, Italy.
⁴⁹Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Italy.
⁵⁰Department of Radiation Medicine and Applied Sciences, Department of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla.
⁵¹Department of Neurosciences, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla.
⁵²Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, United Kingdom.
⁵³Chalfont Centre for Epilepsy, Bucks, United Kingdom.
⁵⁴Centre for Medical Image Computing, University College London, United Kingdom.
⁵⁵MRI Unit, Epilepsy Society, Chalfont St Peter, Bucks, United Kingdom.
⁵⁶CNNP Lab, ICOS Group, Newcastle University, United Kingdom.
⁵⁷Department of Neurology, Clinical Neuroscience Center, University Hospital and University of Zürich, Switzerland.
⁵⁸Division of Neurology, Department of Medicine, Queen's University, Kingston, Ontario, Canada.
⁵⁹Imaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles.
⁶⁰Neurophysiopathology and Movement Disorders Clinic, Regional Epilepsy Center, University of Messina, Italy.
⁶¹Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard University, Boston, MA.
⁶²Center for Sherbrooke Laboratory for Integrative Connectomics, Centre de Recherche du CHUS, Université de Sherbrooke, Quebec, Canada; and.
⁶³BC Children's Hospital, University of British Columbia, Vancouver, Canada.

⁰Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.

Neurology +

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2025年8月22日

PubMedで要約を見る

まとめ

テンポラルロブ性 (TLE) は,成人の生涯にわたって,典型的な老化を上回る,広範囲にわたる灰白質の縮を引き起こします. 早期診断と介入はこの状態の管理に不可欠です

科学分野

神経イメージング
エピレプシー研究
脳構造分析

背景

側頭葉の (TLE) は,側頭葉の病理と広範な脳構造の変化に関連しています.
TLEの進行性とその時間的進化はよく定義されていません.
TLEの寿命の変化を理解することは,患者の管理に極めて重要です.

研究の目的

TLE患者の灰白質の年齢関連の構造的変化を調査する.
灰色と白質の変化を成人の生涯にわたって表します
脳の両部分の年齢による変化の共変性を調べるため

主な方法

769人のTLE患者と885人の対照群 (17歳から73歳) のMRIデータの大規模分析.
皮質の厚さ,皮質下体積,白質の微細構造 (FA,MD) のグループ別比較とスライディング年齢ウィンドウ分析.
灰色物質と白質物質の寿命曲線の相関関係を調べるコヴァリアンス分析.

主要な成果

TLE患者では,成人期を通じて,広範囲に広がる皮質・皮質下部領域において,重大な灰色質の縮 (厚さ/体積の減少) を示した.
広く白質の変化 (FA減少,MD増加) が,特にテンポロリンビア繊維で観察されました.
これらの変化は,特に55歳以上のTLE患者で,灰色と白質の変化との強い関連性を超えた.

結論

TLEの患者は,生涯にわたって,より顕著で広範な灰白質の縮を呈する.
横断的な設計は進行に関する結論を制限しますが,結果はTLEの迅速な診断と介入の必要性を強調しています.
結果は,薬剤耐性性の影響を理解するために,さらなる縦断的な研究の重要性を強調しています.