関連する実験動画

Updated: Sep 10, 2025

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
05:31

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

Published on: May 16, 2025

295

ゲニステインは,CB1受容体の過活性化を抑制し,その媒介によるcAMP- PKAシグナリングを調節することにより,胸腔大動脈解剖を改善する

Yanbang Chi1, Tao Huang2, Jikai Zhao2

  • 1Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China; State Key Laboratory of Frigid Zone Cardiovascular Disease, Department of Cardiovascular Surgery, General Hospital of Northern Theater Command, 83 Wenhua Road, Shenyang, Liaoning 110016, PR China; Department of Obstetrics and Gynecology, General Hospital of Northern Theater Command, 21 Shenyang, 110016, PR China.

Phytomedicine : international journal of phytotherapy and phytopharmacology
|August 22, 2025
PubMed
まとめ

ゲニステイン (Gen) はカンナビノイド1 (CB1) 受容体を阻害し,胸前大動脈解剖 (TAD) に対して保護するためにcAMP- PKAシグナリングを回復します. この研究はTADの治療標的としてCB1受容体を強調しています.

キーワード:
CB1 についてジェニステインPKA について胸部大動脈の解剖血管の滑らかな筋肉細胞

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