トランスクラニアル磁気刺激は,放射線学的に孤立した症候群における早期の皮質異常を特定する

Merve Bahar Ercan¹, Evren Boran², Emine Altin¹

¹Gazi University Faculty of Medicine, Department of Neurology, Ankara, Turkey.

Multiple sclerosis and related disorders

|August 22, 2025

まとめ

放射線隔離症候群 (RIS) は,頭蓋骨間磁気刺激 (TMS) によって検出される早期の臨床下皮質および半球間機能障害を示し,早期のMSリスクの特定の可能性を示しています.

科学分野:

神経科学
神経科学
バイオマーカー

背景:

放射線隔離症候群 (RIS) は多発性硬化症 (MS) の臨床前段階である.
RISでは脱ミエリーニゼーションの病変が検出されました
トランスクラニアル磁気刺激 (TMS) は,脱ミエリネーションとニューロン喪失に関連した皮質脊髄機能障害を検出します.

研究の目的:

TMSを用いてRISにおける運動皮質刺激性を調査する.
RISにおけるTMSの発見,認知,疲労,MRIの特徴との関係を調べる.

主な方法:

16人のRIS患者と16人の対照群は,RMT,MEP遅延,CMCT,CSP,SICI,SAIなどのパラメータを評価するためにTMSを受けた.
認知機能はSDMTで評価され,疲労はFSMCで評価される.
TMSのパラメータ,認知,疲労,MRIの損傷負荷の間の相関分析

主要な成果:

RISの患者は長時間CMCTとiCSPを示し,対照群と比較してMEPの遅延期が増加する傾向がありました.
グループ間のRMT,CSP,SICI,またはSAIの有意な差異はありません.
RISの参加者はSDMTのスコアが低く,FSMCのスコアが高かった.
TMSのパラメータはMRIの病変の特徴と相関しなかった.

結論:

RISにおける早期の臨床下脊髄および半球間機能不全が示唆されている.
TMSは多発性硬化症の転移リスクが高い個人を特定するための機能的なバイオマーカーとして有望である.
TMSとMRIの組み合わせは MSの早期発見とリスクの階層化を高めます

キーワード:

認知能力エンジンの誘発電源多発性硬化症放射線学的に孤立した症候群トランスクラニアル磁気刺激

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