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システインは,多胞性卵巣症候群との基本微量元素の関連を媒介する.環境の微粒子の曝露は,システインの媒介効果を変化させるか.

Rui Dong ¹, Shiwei Ren ¹, Xin Wang ²

¹Department of Public Health Inspection and Quarantine, school of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, Anhui 230032, China; Anhui Medical University, No 81 Meishan Road, Hefei, Anhui 230032, China.
²Department of Ultrasound, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China.
³Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei, Anhui 230022, China.
⁴Anhui Medical University, No 81 Meishan Road, Hefei, Anhui 230032, China.
⁵Department of Public Health Inspection and Quarantine, school of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, Anhui 230032, China.
⁶Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei, Anhui 230022, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei, Anhui 230032, China; Anhui Provincial Engineering Research Center of Biopreservation and Artificial Organs, No 81 Meishan Road, Hefei, Anhui 230032, China; Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei, Anhui 230032, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China.
⁷Anhui Medical University, No 81 Meishan Road, Hefei, Anhui 230032, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, Anhui 230032, China; Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei, Anhui 230032, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China.
⁸Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei, Anhui 230022, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei, Anhui 230032, China; Anhui Provincial Engineering Research Center of Biopreservation and Artificial Organs, No 81 Meishan Road, Hefei, Anhui 230032, China; Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei, Anhui 230032, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China; Center for Big Data and Population Health of IHM, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
⁹MEEKL-AERM, College of Environmental Sciences and Engineering, Institute of Tibetan Plateau, and Center for Environment and Health, Peking University, Beijing 100871, China.
¹⁰Department of Public Health Inspection and Quarantine, school of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, Anhui 230032, China; Department of Obstetrics and Gynaecology, the First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei, Anhui 230022, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei, Anhui 230032, China; Anhui Provincial Engineering Research Center of Biopreservation and Artificial Organs, No 81 Meishan Road, Hefei, Anhui 230032, China; Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei, Anhui 230032, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China.

⁰Department of Public Health Inspection and Quarantine, school of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, Anhui 230032, China; Anhui Medical University, No 81 Meishan Road, Hefei, Anhui 230032, China.

Ecotoxicology and Environmental Safety +

|

2025年8月22日

PubMedで要約を見る

まとめ

亜鉛,コバルト,銅などの微量元素はPCOSリスクの低下と関連しており,システインはこの効果を媒介しています. 微粒子の曝露は,この関係を変化させ,PCOSの環境要因を強調します.

科学分野

環境健康
生殖内分泌学
微量元素の代謝

背景

多囊性卵巣症候群 (PCOS) は複雑な内分泌疾患で,環境要因と関連している可能性があります.
欠かせない微量元素は抗酸化防御を含む様々な生物学的プロセスにおいて重要な役割を果たします

研究の目的

葉っぱ液 (FF) の微量元素濃度とPCOSとの関連を調査する.
システイン (Cys) が微量元素とPCOSの関係を媒介するかどうかを判断する.
この媒介に対する環境粒子 (PM) 曝露の影響を調べる.

主な方法

420人のPCOS患者と408人の対照群を対象としたケース・コントロール研究.
8つの微量元素とFFのCysレベルを分析した.
最近のPM曝露の推定とベイジアンカーネルマシン回帰 (BKMR) の適用
PM-Cys関係の分散ラグ線形モデルと並行して,従来のモデルとピースワイドモデルを用いたメディエーション分析.

主要な成果

FF微量元素濃度の上昇は,PCOSの確率の低下と関連していた.
システインは,タン (Sn),コバルト (Co),銅 (Cu) とPCOSの間の逆関係を有意に媒介した.
PMの暴露はCysレベルと逆の関係を示した.
PM暴露はCysの媒介効果を変化させ,低PM群では媒介が観察されたが,高PM群ではCoとCuでは媒介は観察されなかった.

結論

チン,コバルト,銅は,システイン濃度の正の変化によって媒介されるPCOSと否定的な関連を示しています.
微粒子の曝露は,微量元素とPCOSとの関連におけるシステインの媒介的役割を変化させるようです.
PMの改変効果を確認し,その背後にあるメカニズムを明らかにするために,さらなる研究が必要である.

キーワード:

システイン主要な微量元素微粒子の曝露多囊性卵巣症候群変化する効果

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