Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Antimicrobial Proteins01:23

Antimicrobial Proteins

5.1K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
5.1K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

917
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
917
Inflammatory Response01:28

Inflammatory Response

7.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
7.1K
T Cell Types and Functions01:24

T Cell Types and Functions

1.4K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.4K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

62
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
62
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

12.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.3K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Friend or foe? IFNλ drives fibrosis.

The Journal of experimental medicine·2026
Same author

Systematic comparison of triglyceride-glucose (TYG)-index with other mortality predictive models in obese patients with different mortality rates.

Cardiovascular diabetology·2026
Same author

A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines.

Nature immunology·2026
Same author

Won't you be my neighbor? Control of the immune response by stromal and immune cell microenvironments within the lymph node.

Current opinion in immunology·2026
Same author

Molecular, Cellular, Tissue, and Organismal Functions of Type III Interferons.

Annual review of immunology·2026
Same author

Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.

bioRxiv : the preprint server for biology·2025

関連する実験動画

Updated: Sep 10, 2025

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

13.5K

健康と病気におけるインターフェロン

Daniel Boehmer1, Ivan Zanoni2

  • 1Harvard Medical School and Boston Children's Hospital, Division of Immunology, Division of Gastroenterology, Boston, MA 02115, USA; Department of Medicine II, University Hospital, LMU Munich, 81377 Munich, Germany.

Cell
|August 22, 2025
PubMed
まとめ

インターフェロン (IFN) は,健康と病気における二重の役割を持つ重要なシグナルタンパク質です. IFNのバランスの取れた産生は感染症からの保護に不可欠であり,不均衡は炎症や自己免疫状態を引き起こす可能性があります.

科学分野:

  • 免疫学
  • 分子生物学
  • 細胞生物学

背景:

  • インターフェロン (IFN) は,免疫反応に関与する重要なシグナル伝達タンパク質です.
  • 異なるタイプのIFN (I,II,III) は,ジャヌスキナーゼ経路を通して信号を送る.
  • IFNには2つの役割があり 病原体から身を守るだけでなく 自己免疫疾患にも貢献します

研究 の 目的:

  • IFN誘導と応答のメカニズムを見直す
  • 感染症,がん,免疫媒介疾患におけるIFNの役割を強調する.
  • 特に粘膜組織におけるIFNのバランスの取れた生成の重要性を強調する.

主な方法:

  • 細胞および分子メカニズムに関する文献レビュー.
  • 様々な病気の状況におけるIFNの役割の分析
  • IFN信号のタイムダイナミクスにフォーカスする.

主要な成果:

  • IFNは細菌,ウイルス,真菌感染と戦うために不可欠です.
  • 調節不良のIFN反応は,炎症性,自己免疫性,遺伝性疾患に関与しています.
  • 粘膜組織は,IFNの活動と失調のための重要な場所です.

さらに関連する動画

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
10:10

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses

Published on: November 16, 2016

13.8K
Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
08:26

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

Published on: June 14, 2018

12.1K

関連する実験動画

Last Updated: Sep 10, 2025

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

13.5K
Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
10:10

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses

Published on: November 16, 2016

13.8K
Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
08:26

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

Published on: June 14, 2018

12.1K

結論:

  • 保護的な免疫のために,時間の経過とともにバランスのとれたIFNファミリー生成が必要である.
  • このバランスの喪失は 自己免疫疾患を含む有害な結果をもたらします
  • IFNのダイナミクスを理解することは 効果的な治療戦略の開発の鍵です