Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

77
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
77
Inflammation01:38

Inflammation

55.1K
Overview
55.1K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

33
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
33
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

34
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
34
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

55
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
55

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Generalization of AI-Based Gestational Age Assessment Using Blind Sweep Ultrasonography.

JAMA network open·2026
Same author

Estimating high-resolution albedo for urban applications.

Nature communications·2026
Same author

Inter-facility travel time and referral for emergency obstetric care in the 15 most populated cities of Nigeria: a spatial analysis.

BMC global and public health·2026
Same author

Impact of using artificial intelligence as a second reader in breast screening including arbitration.

Nature cancer·2026
Same author

Diagnostic accuracy, fairness and clinical implementation of AI for breast cancer screening: results of multicenter retrospective and prospective technical feasibility studies.

Nature cancer·2026
Same author

TRIB3 Links Endoplasmic Reticulum Stress to Impaired Efferocytosis in Atherosclerosis.

Circulation research·2025

関連する実験動画

Updated: Sep 10, 2025

Real-Time, High-Throughput Microscopic Quantification of Human Neutrophil Extracellular Trap Release and Assessing the Pharmacology of Antagonists
11:32

Real-Time, High-Throughput Microscopic Quantification of Human Neutrophil Extracellular Trap Release and Assessing the Pharmacology of Antagonists

Published on: October 18, 2024

720

動脈硬化症の原動力としての中性細胞外トラップ (NETs):病原性メカニズムと治療の可能性

Shravya Shetty1, Manikandan Subramanian2

  • 1Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK.

Pharmacology & therapeutics
|August 22, 2025
PubMed
まとめ

中性粒子の細胞外トラップ (NETs) は,動脈硬化症の進行と心血管疾患の有害事象において重要な役割を果たします. 生命を脅かす病気と闘うための 新しい治療戦略です

キーワード:
動脈硬化症DNase について炎症NET クリアランスNET症候群中性粒子の細胞外トラッププラークの脆弱性

さらに関連する動画

Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein
07:26

Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein

Published on: August 12, 2025

59
A High-throughput Assay to Assess and Quantify Neutrophil Extracellular Trap Formation
09:59

A High-throughput Assay to Assess and Quantify Neutrophil Extracellular Trap Formation

Published on: January 29, 2019

10.1K

関連する実験動画

Last Updated: Sep 10, 2025

Real-Time, High-Throughput Microscopic Quantification of Human Neutrophil Extracellular Trap Release and Assessing the Pharmacology of Antagonists
11:32

Real-Time, High-Throughput Microscopic Quantification of Human Neutrophil Extracellular Trap Release and Assessing the Pharmacology of Antagonists

Published on: October 18, 2024

720
Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein
07:26

Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein

Published on: August 12, 2025

59
A High-throughput Assay to Assess and Quantify Neutrophil Extracellular Trap Formation
09:59

A High-throughput Assay to Assess and Quantify Neutrophil Extracellular Trap Formation

Published on: January 29, 2019

10.1K

科学分野:

  • 心血管科学
  • 免疫学
  • 病理学について

背景:

  • 心血管疾患 (CVD) は世界の主要な死因です.
  • 慢性的な炎症性疾患である動脈硬化症は 大抵の心血管疾患の根底にあるもので 動脈のプラークの蓄積が特徴です
  • マクロファージやリンパ球などの免疫細胞は研究されていますが,動脈硬化症における中性粒子の役割はあまり理解されていません.

研究 の 目的:

  • 動脈硬化症における中性粒子の細胞外トラップ (NETs) の重要な役割を検討する.
  • この状態でNETosisを駆動するメカニズムを調べる.
  • NETを標的とした新しい治療戦略を探求する.

主な方法:

  • ニュートロフィール,NET,動脈硬化に関する研究の包括的な文献レビュー.
  • NETosisとNETクリアランスのメカニズムの分析
  • プラークの進行と臨床的結果におけるNETの病原性作用の検討

主要な成果:

  • 中性粒子の細胞外トラップ (NET) は,炎症体の活性化とプラークの不安定性における役割としてますます認識されています.
  • NETは動脈硬化症の進行に寄与し,動脈血栓症のリスクを高めます.
  • 機能不全のNETクリアランスは,それらの病原性効果を悪化させる.

結論:

  • 中性粒子の細胞外トラップ (NET) は,動脈硬化症の病原化に大きく寄与する.
  • NETの形成をターゲットにしたり,NETのクリアランスを促進したりすることは,新しい心血管療法にとって有望な道を示しています.
  • NETを標的とした介入に関するさらなる研究は,動脈血栓症とその合併症を緩和する可能性がある.