関連する実験動画
Updated: Sep 10, 2025

09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
16.0K
ナノスケールの薬物投与システムによる肝臓吸収回避戦略
Yanling Zhang1, Dawei Chen1, Ming Zhao1
1Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, PR China.
International journal of pharmaceutics
|August 22, 2025
まとめ
ナノスケールの薬物投与システム (NDDS) は有望ですが,ナノ粒子 (NP) はしばしば肝臓によって捕獲されます. 肝臓への吸収を回避する戦略は,効果的な肝臓外標的と臨床使用に不可欠です.
科学分野:
- 生物医学工学
- ナノテクノロジー
- 薬理学について
背景:
- ナノスケール薬剤投与システム (NDDS) は治療効果を高め,副作用を減らすことができます.
- ナノ粒子 (NP) の肝臓捕獲は,肝臓外標的を阻害することによって,それらの臨床的応用を制限する.
研究 の 目的:
- NDDSの概念,特性,およびアプリケーションをレビューする.
- NPの肝臓吸収とクリアランスのメカニズムを解明する.
- 肝臓の吸収を回避する戦略を強調し,薬剤の投与を改善する.
主な方法:
- NDDSとNPの相互作用に関する既存の文献のレビュー.
- 肝臓でのNPの吸収とクリアランスのメカニズムの分析
- 肝臓捕獲を減らすためのNP特性を調節する戦略と投与の議論
主要な成果:
- 肝臓捕獲は,NDDSの臨床翻訳に重大な障壁である.
- 物理化学的性質,表面の変化,投与経路の調節により,NPの肝臓吸収が減少する可能性があります.
- NPの行動を in vivoで評価するための様々な評価方法が存在します.
結論:
- NDDSの治療可能性を最大化するために肝臓の吸収を回避することが重要です.
- 効果的な肝臓外標的化を達成するために,NPの戦略的設計が必要である.
- NDDSにおける肝臓クリアランスの課題を克服するために,さらなる研究と開発が必要である.
関連する概念動画
Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport
806
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
806
Drug Delivery: Overview
422
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
422
Drug Elimination: Non-Renal Routes
2.5K
The liver plays a pivotal role in eliminating drugs and their metabolites, primarily through a process known as biliary excretion. This process involves the hepatocytes, the primary cells in the liver that generate bile. A range of transporters actively expels polar drugs or hydrophilic drug metabolites into the bile, which transports the drugs and metabolites into the small intestine. From here, they are eventually expelled from the body through feces. In some instances, the original drug or a...
2.5K
Factors Influencing Drug Absorption: Presystemic Elimination
340
The pharmacokinetic journey of oral drugs begins with a crucial first pass through the hepatic portal system, called the first-pass effect. This first pass significantly impacts bioavailability — the proportion of a drug that enters systemic circulation and is available for therapeutic action. The primary route sees the drug absorbed by intestinal membranes and then shunted to the liver via the hepatic portal vein. Here, pre-systemic elimination occurs as drugs face metabolism or biliary...
340
Drug Delivery: Enteral Route
715
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
715
Factors Affecting Dissolution: Particle Size and Effective Surface Area
1.0K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.0K

