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Updated: Sep 10, 2025

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アリストロヒン酸Iは,マンナンを結合するレクチンセリンプロテアゼ1-補足系を活性化することによって,腎管間繊維症を促進する

Chen Wang1, Hong Zhang1, Jiahe Wang1

  • 1Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
|August 22, 2025
PubMed
まとめ

アリストロヒン酸I (AAI) はMASP1補足経路を活性化することで腎臓線維症を引き起こす. マナン結合レクチンセリンプロテアゼ1 (MASP1) を阻害すると,炎症と線維症が軽減され,潜在的な治療標的となる.

キーワード:
AAI について補足システムMASP1 についてMASP2 についてRIF について

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