心筋機能の指標としての心筋機能指数
Dorothee Brunet1, Simon Dang Van2, Martin Klockner1
1Department of Cardiac Surgery and Transplantation, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, Le Plessis Robinson, France.
まとめ
エックス・シトゥ・ハート・ペルフュージョン (ESHP) は,生存能力の評価を可能にします. 心筋機能指数 (MWI) は,ESHP中の心臓機能と強く相関しており,新しいプラットフォームの開発を支援しています.
科学分野:
- 心血管外科
- 移植医学
- 医療機器
背景:
- 臓器の不足により 臓器移植の際には 心臓移植が必要になります
- 現在のエックス・シトー・ハート・ペルフュージョン (ESHP) の方法は,機能的生存能力の評価が欠けている.
- エコーカルディオグラフィーは 非侵襲的な評価の可能性を提供します.
研究 の 目的:
- エコーカルディオグラフィック・ミオカルディアル・ワーク・インデックス (MWI) とESHP中の心臓のパフォーマンスとの関係を調査する.
- ESHPにおける非侵襲的なエコーカルディオグラフィの可行性を評価する.
主な方法:
- 18の豚の心臓は冷凍保存,低温浸出,循環死グループに分けられました.
- ノルモサーミックESHPは,作業モードの設定を使用して実行されました.
- 心拍数とMWIはエコーカーディオグラフィを用いて測定された.
主要な成果:
- 心臓の出力とMWIの有意な差異が観察された (p<0. 012).
- MWIは心臓の出力量と強い正の相関関係を示した (r=0. 85, p<0. 001).
- ESHP中のMWIのエコーカルディオグラフィの評価は可能である.
結論:
- MWIは,ESHP中の心臓のパフォーマンスの信頼できる指標です.
- 作業モードの機能を持つ統合されたESHPプラットフォームの開発を支援します.
- 移植後のデータを含むさらなる研究が必要である.
さらに関連する動画
08:01Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System
Published on: June 11, 2020
8.2K
08:21Functional Assessment of the Donor Heart During Ex Situ Perfusion: Insights from Pressure-Volume Loops and Surface Echocardiography
Published on: October 11, 2022
2.2K
関連する概念動画
01:05Pulse
The pulse is one of the most fundamental physiological indicators of the body's cardiovascular health. It is the rhythmic expansion and contraction of the arterial walls in response to the pressure generated by the heart's pumping action.
Pulse Rate and its Significance
Pulse rate, often measured in beats per minute (bpm), reflects the heart rate (HR), which is influenced by numerous factors such as stress, physical activity, and hormonal changes. A normal resting adult pulse rate falls between...
Pulse Rate and its Significance
Pulse rate, often measured in beats per minute (bpm), reflects the heart rate (HR), which is influenced by numerous factors such as stress, physical activity, and hormonal changes. A normal resting adult pulse rate falls between...
01:17Pulse amplitude and quality
Pulse amplitude is a crucial indicator of cardiac health because it provides valuable insights into the strength of left ventricular contractions and the overall uniformity of blood circulation within the vasculature. The strength of the pulse is directly related to the force with which the heart contracts and the volume of blood being pumped.
A weak or absent pulse may indicate reduced cardiac output or poor left ventricular contraction, which can be signs of cardiovascular dysfunction or...
A weak or absent pulse may indicate reduced cardiac output or poor left ventricular contraction, which can be signs of cardiovascular dysfunction or...
01:16Pulse
When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
The pulse serves as a clinical indicator...
The pulse serves as a clinical indicator...
01:27Assessment of the Cardiovascular System III: Palpation
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:26Exercise Stress Test
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes