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Updated: May 13, 2026

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Junyu Luo1, Man Jiang2, Jun Liu1

  • 1Department of Neurology & Institute of Neurology, Ruijin Hospital Affiliated to Medical College of the Shanghai Jiao Tong University, Shanghai 200025, China.

Journal of genetics and genomics = Yi chuan xue bao
|August 22, 2025
PubMed
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No abstract available in PubMed .

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Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...