関連する実験動画

Updated: Sep 10, 2025

Adult Mouse DRG Explant and Dissociated Cell Models to Investigate Neuroplasticity and Responses to Environmental Insults Including Viral Infection
09:23

Adult Mouse DRG Explant and Dissociated Cell Models to Investigate Neuroplasticity and Responses to Environmental Insults Including Viral Infection

Published on: March 9, 2018

21.8K

傷による脊髄損傷は,小さな感覚ニューロンの興奮を調節するNav1.8機能障害を引き起こします

Yucheng Xiao1, Yanling Pan1, Naikui Liu2

  • 1Department of Biology, School of Science, Indiana University-Indianapolis, Indianapolis, IN, USA.

The Journal of physiology
|August 22, 2025
PubMed
まとめ

脊髄損傷 (SCI) は,感覚ニューロンの特定のナトリウム電流 (Nav1.8) を増加させることで痛みを増幅します. 新しい化合物ZL0177は これらのチャネルを標的とし 痛み信号を減少させ SCIの痛みに対する 潜在的な治療戦略を提供します

キーワード:
DRGニューロン痛みを感じる再生ナトリウム電流ナトリウムチャネル脊髄損傷

さらに関連する動画

Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats08:57

Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats

Published on: April 4, 2012

23.8K
A Neonatal Mouse Spinal Cord Compression Injury Model13:31

A Neonatal Mouse Spinal Cord Compression Injury Model

Published on: March 27, 2016

12.7K

関連する概念動画

Spinal Cord: Information Processing01:10

Spinal Cord: Information Processing

The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
1.7K
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
930
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.0K
Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
1.2K
Spinal Cord01:26

Spinal Cord

The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
591
The Spinal Cord01:54

The Spinal Cord

The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
29.7K