関連する実験動画

Updated: Sep 10, 2025

Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags
10:10

Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags

Published on: January 17, 2019

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タンパク質とタンパク質の相互作用のための分解しない分子接着剤の探索

Sitong Yu1, Lixin Zhou2, Jing Yang3

  • 1Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China; Lingang Laboratory, Shanghai 200031, China.

Trends in biochemical sciences
|August 22, 2025
PubMed
まとめ

非分解性分子接着剤 (MGs) は,タンパク質とタンパク質の相互作用 (PPI) をユビキチン化なしに安定させ,新しい治療戦略を提供します. このレビューでは,MGsの進歩を強調し,主要なタンパク質とその広範な翻訳の可能性に焦点を当てています.

キーワード:
化学的に誘発された近接性分子接着剤タンパク質とタンパク質の相互作用安定剤

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