高等教育病院における Mycobacterium kansasii 複合性肺感染症に関する遡及コホート研究
Yi-Chi Lin1, Hsiu-Hui Lee2, Chong Kei Lao1
1Division of Infectious Diseases, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, 5 Fuxing St., Guishan Dist., Taoyuan 33305, Taiwan.
Mycobacterium kansasii複合性肺疾患 (MKC- PD) のアウトカムは,患者の年齢,BMI,および治療期間に依存する. 早期のリスク評価は,MKC- PD患者における治療の成功の改善の鍵です.
科学分野:
- 肺医学
- 感染症
- 微生物学
背景:
- Mycobacterium kansasii複合体 (MKC) は重度の構造的損傷を伴う慢性肺疾患を引き起こす.
- MKC肺疾患 (MKC- PD) は,進行する呼吸器系症状を伴う.
研究 の 目的:
- MKC-PDの予後要因を特定する.
- MKCの遺伝子型と抗菌感受性を決定する.
- MKC- PD患者の治療結果を評価する.
主な方法:
- 台湾のリンカウ・チャン・ガン・メモリアル病院で実施された遡及コホート研究 (2016年-2021年).
- ATS/ERS/ESCMID/IDSA基準に基づく診断
- hsp65またはtuf遺伝子の配列化による種化;Sensititre RAPMYCO2による感受性試験
主要な成果:
- 治療の成功率は46. 2%,失敗率は53. 8%でした.
- 年齢,BMI,および治療期間に関する予測結果.
- 21/33 (63%) のリファムシン耐性菌株は Mycobacterium persicum でした.
結論:
- MKC- PDの治療結果は,年齢,BMI,治療期間と関連しています.
- MKC-PD治療の成功を高めるには,個別化されたリスクの階層化が不可欠です.
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