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Updated: Sep 10, 2025

Live-imaging of Breast Epithelial Cell Migration After the Transient Depletion of TIP60
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Live-imaging of Breast Epithelial Cell Migration After the Transient Depletion of TIP60

Published on: December 7, 2017

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タンパク質アルギニンメチルトランスフェラーゼ5は,メルケル細胞がんにおけるSRSF1経由でTip60-EP400複合体を維持する

Joseph L Sevigny1,2, Evelyn V Proctor1, Heather Adams1

  • 1Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.

Life science alliance
|August 22, 2025
PubMed
まとめ

タンパク質アルギニンメチルトランスフェラーゼ5 (PRMT5) は,MYCL誘発がんにおけるTip60- EP400複合体の活性に決定的なSRSF1を改変することによって,RNAのスプライシングを調節する. PRMT5の阻害はスプライシングの欠陥を引き起こし,潜在的な治療戦略を提供します.

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