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Updated: Sep 10, 2025

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes
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Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes

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ウィーバー症候群に関連したEZH2変異の支配的ネガティブ効果

Orla Deevy1,2, Jingjing Li1, Craig Monger1

  • 1Smurfit Institute of Genetics, Trinity College Dublin, Dublin 4, Ireland.

Genes & development
|August 22, 2025
PubMed
まとめ

EZH2のウィーバー症候群変異はポリコンブ抑制複合体2 (PRC2) の機能を破壊し,ヒストンのメチル化と遺伝子発現に影響を与えます. この支配的ネガティブメカニズムは 染色体と成長制御に影響を与え 発達障害の洞察力を提供します

キーワード:
EZH2 についてPRC2についてポリコンブウィーバー症候群発達 過剰 成長主要なネガティブゲノムプロファイリング成長制限アイソジェニック珍しい病気

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X-chromosome...
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