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Updated: Sep 10, 2025

Quantitative Methods to Study Protein Arginine Methyltransferase 1-9 Activity in Cells
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PRMT5:MTAPで削除されたがんに対する有望な合成致死標的

Bang Li1, Jin-Qi Yu1, Zhenjiao Yang1

  • 1Balance-Based Drug Discovery Laboratory, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.

Journal of medicinal chemistry
|August 22, 2025
PubMed
まとめ

第2世代のPRMT5阻害剤は,MTAPの削除を選択的に標的とした精密腫瘍学的アプローチを提供します. この戦略は,以前のPRMT5阻害剤で観察された血液学的毒性を克服します.

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