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Updated: Sep 10, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
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Granulocyte-dependent Autoantibody-induced Skin Blistering

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Pemphigus vulgarisにおけるデスマグリーン主導のダイナミックシグナル伝達:病原性経路の体系的なレビュー

Siavash Rahimi1,2,3, William V J Hariton1,2, Fattaneh Khalaj4

  • 1Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

NPJ Regenerative medicine
|August 22, 2025
PubMed
まとめ

デスモソーマルカデリンは上皮の整体性と信号を維持する. ペンフィガス・ヴルガリスの研究のレビューでは この自己免疫疾患に関与する128のシグナル分子を明らかにし 治療の洞察を提供しました

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The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
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The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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