食事による炎症指数 (DII) のスコアと子どもの注意欠陥多動性障害 (ADHD) の関連
Fatemeh Navab1,2,3, Khadijeh Abbasi1,2, Hajar Heidari1,2
1Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Scientific reports
|August 22, 2025
まとめ
エネルギー調整による食事による炎症指数 (E-DII) の上昇は,イランの子供における注意欠陥多動性障害 (ADHD) のリスクの増加と関連していた. この発見はADHDの発症に 食事の役割があることを示唆しています
科学分野:
- 神経発達障害
- 栄養学
- 小児の健康
背景:
- 注意欠陥多動性障害 (ADHD) は,不完全な病因が理解されている一般的な神経発達障害である.
- 遺伝,家族歴,栄養,ライフスタイル,炎症などの要因が ADHD の発症に関与しています
- ダイエット炎症指数 (DII) は,食事による炎症の可能性を定量化します.
研究 の 目的:
- ダイエット炎症指数 (DII) と子供のADHDのリスクとの関連を調査する.
- 食事による炎症の可能性が 小児集団におけるADHDと関連しているかどうかを判断する.
主な方法:
- 4歳から12歳のイランの子供500人 (ADHD患者200人,健康な対照群300人) を対象としたケース・コントロール研究.
- 168項目の食品頻度アンケート (FFQ) を用いて食事摂取量を評価し,エネルギー調整DII (E-DII) スコアを計算した.
- 統計分析には,ANCOVAと多変数ロジスティック回帰があり,年齢,性別,所得,BMIを調整した.
主要な成果:
- エネルギー調整された食事による炎症指数 (E-DII) はADHDリスクと有意な直接的な関連を示した.
- ADHDのオッズ比 (ORs) は,原始,モデル1およびモデル2の分析において,より高いE-DIIスコアで増加した (p < 0. 05).
- 具体的には,ORは1.104から1.162の範囲で,より炎症を誘発するダイエットによりリスクが高まっていることを示しています.
結論:
- 高いE-DIIスコアはイランの子供たちのADHDリスクと 大きく関連しています
- 炎症の可能性が高い食事パターンはADHDの発症に寄与する可能性があります.
- 研究の限界を考慮して,これらの発見を確認し,因果関係を調査するためにさらなる研究が必要です.
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