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Updated: Sep 10, 2025

Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography
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マイクロ秒分子動態シミュレーションで観察されたオレキシン受容体2型とレムボレクサントによる非正規のGq活性化

Paulina Dragan1, Valerie Gratio2,3, Thierry Voisin2

  • 1Faculty of Chemistry, University of Warsaw, 02-093, Warsaw, Poland.

Scientific reports
|August 22, 2025
PubMed
まとめ

睡眠障害薬であるレムボレクサントは,がん細胞のオレキシン受容体 (OX2) を活性化し,アポトーシスを促進する可能性があります. 分子ダイナミクスシミュレーションでは,レムボレクサントとアゴニストが同様のOX2受容体変化を誘導し,がん細胞への影響を説明しています.

キーワード:
GDP/GTPの交換Gqタンパク質の活性化レムボレクサント分子動力学OX2 についてオレキシン受容体信号変換

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