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Updated: Sep 10, 2025

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
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Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method

Published on: October 23, 2018

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α-ケトグルタレットは,ヒトがんにおけるエネルギー感知のためのAMPKタンパク質合成を決定する

Wen Mi1, Yun Xue2, Haohang Yan1

  • 1Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology; Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Fudan University, Shanghai, China.

Nature chemical biology
|August 22, 2025
PubMed
まとめ

メタボライトであるα-ケトグルタレート (α-KG) は,TET- YBX1経路を通じてAMP活性化タンパク質キナーゼ (AMPK) 変換を調節する. この軸をターゲットにすると 癌細胞がエネルギーストレスに 敏感になり 新しい治療戦略が生まれます

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