女性生殖因子の関節炎リスクとの関連:人口ベースの横断研究

Jiajia Wang¹, Yiting Ge², Jingbo Xu³

¹Department of Rheumatology, Shaoxing People's Hospital (The First Affiliated Hospital, Shaoxing University), No. 568 Zhong Xing Road, Shaoxing, Zhejiang, 312000, China.

Reproductive health

|August 23, 2025

まとめ

早期または後期に初めての出産をした女性は関節炎のリスクが高くなります. 第一次出産時の年齢のような生殖に関する要因は関節炎の予防とスクリーニングの戦略において極めて重要です

科学分野:

生殖健康
流行病学について
リウマトロジ

背景:

女性の生殖因子は慢性疾患の流行に潜在的に影響を及ぼすことがますます認識されています
生殖歴と関節炎の関係を理解することで公衆衛生戦略に情報を与えることができます

研究の目的:

女性における主要な生殖因子と関節炎の流行の関連を調査する.
具体的には,関節炎に関連して最初の出生年齢 (AFB),最後の出生年齢 (ALB),妊娠数,および生産数を調べる.

主な方法:

1999年から2018年までの全国保健栄養調査 (NHANES) の横断データ分析
多変量ロジスティック回帰,制限立方スライン (RCS) モデル,およびサブグループ分析を使用した.
確固たる結果を得るために混同要因を考慮して調整しました

主要な成果:

AFBと整体関節炎の流行,骨関節炎 (OA),関節リウマチ (RA),その他の関節炎の妊娠の間にU型相関が観察されました.
OAとRAの妊婦の間で J型の関連性が見つかりました.
ALBと関節炎の有病率との間には否定的な相関関係があり,ALBとOA/他の関節炎と他の関節炎の妊娠の間には特定の線形否定的な相関関係がありました.

結論:

初出産時の若さや遅い年齢 (AFB) は,後に関節炎 (OAとRA) を発症する確率が高くなります.
AFB と ALB を含む生殖因子は,関節炎のスクリーニングと予防の取り組みにおいて重要な考慮事項です.
妊娠数と生まれた子供の数も関節炎の流行と複雑で時には逆の関係を示しています

キーワード:

関節炎横断的な研究女性生殖因子骨関節炎リウマチ性関節炎

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