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Updated: Sep 10, 2025

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
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PAD1によって触媒化されたAKT2のシトルリネーションは,卵巣がんにおける卵巣がんのような幹細胞の幹細胞特性維持を促進する

Teng Xue1, Xiaoqiu Liu2, Chao Song3

  • 1Department of Histology and Embryology, College of Basic Medical Science, China Medical University, Shenyang, 110122, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|August 23, 2025
PubMed
まとめ

卵巣がんのような幹細胞 (OCSLC) は腫瘍の進行を促します. 研究者らは,ペプチダルギニンデミナーゼ1 (PAD1) がAKT2を活性化させ,卵巣がん (OC) のステム性およびシスプラチン耐性を促進することを発見した. PAD1をターゲットにすることで,化学療法に対する感受性を回復させることができます.

キーワード:
AKT2 についてPAD1 についてシトルリン化卵巣がんのような幹細胞ストームネス維持

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