リウマチ性関節炎患者のサルコペニック肥満の特徴

Yuma Saito¹, Mochihito Suzuki¹, Toshihisa Kojima^1,2

¹Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Geriatrics & gerontology international

|August 23, 2025

まとめ

サルコペニ性肥満は,関節リウマチ患者の8. 4%に影響し,身体機能と生活の質を著しく低下させます. これは,関節リウマチの管理に標的を絞った介入の必要性を強調しています.

科学分野:

リウマトロジ
ゲロントロジー
代謝健康

背景:

リウマチ性関節炎 (RA) は慢性炎症性疾患である.
サルコペニアと肥満は高齢者集団に多く見られ,サルコペニ性肥満として共存することがあります.
RA患者のサーコペニック肥満の流行と影響は十分に理解されていません.

研究の目的:

リウマチ性関節炎 (RA) 患者におけるサルコペニ性肥満の流行を決定する.
軟骨炎の肥満に関連する要因を特定する.
軟骨硬化症における肥満が身体機能と患者報告結果 (PROs) に与える影響を評価する.

主な方法:

40歳から79歳のRA患者321人を対象とした前向きなコホート研究.
確立された基準に基づいて,正常,肥満,サルコペニア,およびサルコペニック肥満のグループに分類する.
身体機能の評価 (例えば,タイムアップとゴーテスト) とPRO (例えば,健康評価アンケート - 障害指数).

主要な成果:

サーコペニックな肥満は,RA患者群の8. 4%で確認された.
サルコペニック肥満グループは,タイムアップ・アンド・ゴー (TUG) と健康評価アンケート - 障害指数 (HAQ-DI) のスコアが著しく高かった.
身体機能の低下とPROは,他のグループと比較してサルコペニック肥満群で観察されました.

結論:

サルコペニック肥満は,よくコントロールされたRA患者の有意な割合 (8. 4%) に影響する.
サルコペニック肥満の患者は,身体機能が著しく低下し,生活の質が低下します.
これらの発見は,RA患者のケアにおいて,サルコペニ性肥満への対処の重要性を強調しています.

キーワード:

体の構成身体機能リウマチ性関節炎サルコペニアサルコペニック肥満

さらに関連する動画

06:31

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

2.4K

03:52

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

505

関連する概念動画

01:24

Obesity

612

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...

612

01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...

01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

01:09

Changes in the Appendicular Skeleton with Age

2.2K

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

2.2K

01:11

Genome-wide Association Studies-GWAS

14.1K

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...