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Updated: Sep 10, 2025

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鬱病の周辺的メカニズム:腸内皮質Per2遺伝子の発現が乱され,腸壁損傷と微生物多様性障害による日経リズム障害のマウスのうつ病的行動を引き起こす

Huiliang Zhang1, Xuan Qin1, Haiyue Song1

  • 1Department of Pathophysiology, Key Laboratory of Ministry of Education/Hubei province for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|August 23, 2025
PubMed
まとめ

シルカディアンリズム障害 (CRD) は腸の健康と脳の機能を損ない,うつ病につながります. 腸内ペリオド2 (Per2) またはトリプトファンの代謝をターゲットにすることで,これらの効果を防ぐことができます.

キーワード:
Per2 について昼夜リズム障害うつ病腸の障壁腸内微生物群ニューロゲネシス神経炎症

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