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Updated: Sep 10, 2025

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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Published on: August 24, 2013

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非同義語SNPに関する計算的洞察:構造的変化から機能的影響まで

Amna Hafeez1, Andleeb Farooq1, Maria Shabbir1

  • 1Department of Bioscience, Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan.

Journal of biomolecular structure & dynamics
|August 23, 2025
PubMed
まとめ

この研究では,がんに関連したPRKCQ遺伝子の6つの高度に病原性単核型多型変異 (SNP) が特定されました. これらの変異は,タンパク質キナーゼCテータ (PKCθ) の安定性と機能に影響し,新しい治療標的を示唆する.

キーワード:
PKCθシングルヌクレオチドポリモーフィズムバイオ情報ツール癌について分子ダイナミクスシミュレーション

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
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