音響バロトラウマにおける衝撃波による酸化ストレスの聴覚分析器への影響
Olga Rzhevska1, Vasyl Troian2, Irina Sinaiko2
1V. N. KARAZIN KHARKIV NATIONAL UNIVERSITY, KHARKIV, UKRAINE.
Wiadomosci lekarskie (Warsaw, Poland : 1960)
|August 23, 2025
まとめ
軽度の爆発性外傷性脳損傷 (METBI) と音響性バロトラウマは酸化ストレスマーカーを増加させ,感覚神経性聴覚障害 (SHL) と相関する. 抗酸化システムの欠乏はこれらの効果を悪化させる.
科学分野:
- 神経科学
- 眼科について
- 聴覚学
背景:
- 軽度の爆発性トラウマ性脳損傷 (METBI) は複雑な聴覚障害を引き起こす可能性があります.
- アコースティック・バロトラウマは 爆発的なTBIの後に起こる重大な合併症です
- 酸化ストレス (OS) はTBIの病理生理学において重要な役割を果たします.
研究 の 目的:
- トラウマ後の酸化ストレス (OS) を測定する.
- OSの強度とSHLの発生との関連を調査する.
主な方法:
- METBIを患った43人の患者群を研究した.
- 血液サンプルでOSマーカー (アルデヒドフェニルヒドラゾン,カルボキシフェニルヒドラゾン) と抗酸化システム成分 (減少グルタチオン,総チオール) を分析した.
- 酸化窒素濃度も測定した.
主要な成果:
- アルデヒドフェニルヒドラゾン (+53. 54%) とカルボキシフェニルヒドラゾン (+50. 51%) が著しく増加した.
- 抗酸化能力の低下:グルタチオンの減少 (-47. 4%) とトータルチオルの減少 (-61. 7%),酸化窒素の減少 (-54. 22%)
- SHLとOSマーカー (APH,CPH) の増加と,グルタチオン欠乏症の減少との間には直接的な相関が認められた.
結論:
- 抗酸化物質の保護の不均衡は,METBI後の微循環障害に寄与する.
- これらの発見は,OSが内耳の微循環に与える影響を強調し,聴覚障害を軽減するための治療目標を示唆しています.
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